Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640431 | 0.88 | KDM4E (0.56) | PLK1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL14161561 | 0.82 | TP53 (0.45) | PLK1PARP1ALDH1A1LMNAMAPT | |
| SCHEMBL14161600 | 0.79 | PARP1 (0.41) | PLK1KDM4EPARP1ALDH1A1L3MBTL1 | |
| SCHEMBL4642112 | 0.74 | KDM4E (0.46) | KDM4EPARP1ALDH1A1L3MBTL1PDE1A | |
| SCHEMBL14161491 | 0.73 | IKBKB (0.48) | KDM4EPARP1ALDH1A1TSHRJAK2 | |
| SCHEMBL11982142 | 0.72 | PLK1 (0.69) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL4737365 | 0.70 | LMNA (0.45) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL18308447 | 0.70 | PLK1 (0.48) | PLK1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL4738832 | 0.69 | SMN1; SMN2 (0.48) | PLK1KDM4EALDH1A1POLBLMNA | |
| SCHEMBL15988852 | 0.68 | PLK1 (0.49) | PLK1KDM4EALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1956016-A1 | Bicyclic acyltryptophanols | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-08-13 | — | — | EP | disclosed |