Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308451 | 0.88 | KDM4E (0.49) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL11982142 | 0.76 | PLK1 (0.69) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL15988852 | 0.75 | PLK1 (0.49) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL15988858 | 0.70 | PLK1 (0.45) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL9110788 | 0.70 | ALDH1A1 (0.51) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL14099207 | 0.70 | PLK1 (0.47) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL16703478 | 0.69 | LMNA (0.44) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL12184928 | 0.69 | PLK1 (0.53) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL4715766 | 0.68 | PLK1 (0.71) | PLK1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL30330021 | 0.68 | PLK1 (0.71) | PLK1KDM4EALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |