Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MC5R | P33032 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207029 | 0.88 | C5AR1 (0.47) | C5AR1OPRM1ALDH1A1THRBKDM4E | |
| SCHEMBL6206609 | 0.86 | C5AR1 (0.46) | C5AR1OPRM1ALDH1A1THRBKDM4E | |
| SCHEMBL5047630 | 0.78 | ALDH1A1 (0.43) | C5AR1OPRM1ALDH1A1THRBKDM4E | |
| SCHEMBL5047628 | 0.78 | C5AR1 (0.44) | C5AR1OPRM1ALDH1A1THRBKDM4E | |
| SCHEMBL5135947 | 0.75 | MAPT (0.48) | C5AR1OPRM1ALDH1A1KDM4EMAPT | |
| SCHEMBL6342543 | 0.74 | C5AR1 (0.56) | C5AR1OPRM1ALDH1A1THRBMEN1 | |
| SCHEMBL5136013 | 0.74 | C5AR1 (0.56) | C5AR1OPRM1ALDH1A1THRBMEN1 | |
| SCHEMBL19002822 | 0.73 | OPRM1 (0.69) | OPRM1ALDH1A1THRBLMNAMEN1 | |
| SCHEMBL5134730 | 0.73 | C5AR1 (0.57) | C5AR1OPRM1ALDH1A1THRBMEN1 | |
| SCHEMBL5136309 | 0.73 | C5AR1 (0.55) | C5AR1OPRM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |