Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410450 | 0.83 | NOTUM (0.40) | NOTUMP2RX7HTR1DHTR1B | |
| SCHEMBL1410120 | 0.81 | LIPG (0.44) | FFAR1 | |
| SCHEMBL2517376 | 0.80 | NOTUM (0.48) | NOTUMP2RX7 | |
| SCHEMBL1410330 | 0.80 | NOTUM (0.59) | NOTUMSLC6A9 | |
| SCHEMBL1410243 | 0.78 | NOTUM (0.57) | NOTUMSLC6A9 | |
| Potassium Ion SCHEMBL1409563 | 0.76 | NOTUM (0.44) | NOTUMP2RX7 | |
| SCHEMBL1410200 | 0.75 | DPP4 (0.45) | NOTUM | |
| SCHEMBL1410383 | 0.72 | NOTUM (0.49) | NOTUMP2RX7FFAR1 | |
| SCHEMBL1410348 | 0.72 | NOTUM (0.49) | NOTUMP2RX7 | |
| SCHEMBL1410375 | 0.70 | KDM4E (0.44) | NOTUMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | NES, BMI1, DOT1L | NOTUM 874/4885P2RX7 802/4885EPHX2 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.