Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | BACE1 | P56817 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.53 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14100732 | 0.85 | SIGMAR1 (0.62) | SIGMAR1ACHEBACE1DRD4DRD3 | |
| SCHEMBL14115981 | 0.84 | SIGMAR1 (0.67) | SIGMAR1ACHEBACE1DRD4DRD2 | |
| SCHEMBL14116235 | 0.83 | SIGMAR1 (0.74) | SIGMAR1ACHEBACE1 | |
| SCHEMBL14100464 | 0.82 | SIGMAR1 (0.64) | SIGMAR1ACHEBACE1DRD4DRD2 | |
| SCHEMBL12642482 | 0.82 | SIGMAR1 (0.72) | SIGMAR1ACHEBACE1 | |
| SCHEMBL14116438 | 0.81 | SIGMAR1 (0.60) | SIGMAR1ACHEBACE1DRD4DRD2 | |
| SCHEMBL14100583 | 0.81 | SIGMAR1 (0.63) | SIGMAR1ACHEBACE1DRD4DRD2 | |
| SCHEMBL14116101 | 0.81 | SIGMAR1 (0.63) | SIGMAR1ACHEBACE1TEAD1 | |
| SCHEMBL14116237 | 0.80 | SIGMAR1 (0.69) | SIGMAR1ACHEBACE1 | |
| SCHEMBL14116441 | 0.80 | SIGMAR1 (0.62) | SIGMAR1ACHEBACE1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |
| EP-1660491-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-06 | — | — | EP | disclosed |