Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14101049 | 0.85 | CCR2 (0.69) | CCR2 | |
| SCHEMBL14629237 | 0.85 | CCR2 (0.69) | CCR2 | |
| SCHEMBL14599192 | 0.84 | CCR2 (0.64) | CCR2CYP11B1CYP11B2 | |
| SCHEMBL14101047 | 0.84 | CCR2 (0.64) | CCR2CYP11B1CYP11B2 | |
| SCHEMBL14101162 | 0.83 | CCR2 (0.54) | CCR2KCNH2 | |
| SCHEMBL14100848 | 0.81 | CCR2 (0.61) | CCR2 | |
| SCHEMBL14101080 | 0.79 | CCR2 (0.49) | CCR2 | |
| SCHEMBL14101101 | 0.79 | CCR2 (0.48) | CCR2KCNH2 | |
| SCHEMBL14599194 | 0.76 | CCR2 (0.66) | CCR2 | |
| SCHEMBL13646017 | 0.76 | CCR2 (0.59) | CCR2KCNH2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501803-B1 | TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2008-08-13 | — | — | EP | disclosed |