Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 7/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15017778 | 0.85 | PLK1 (0.70) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL14025527 | 0.85 | PLK1 (0.76) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL14476092 | 0.83 | PLK1 (0.49) | PLK1HDAC6HDAC2HDAC8EPHX2 | |
| SCHEMBL250247 | 0.82 | HDAC6 (0.80) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL1121661 | 0.81 | PLK1 (1.00) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL10153931 | 0.81 | PLK1 (0.70) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL14391650 | 0.79 | PLK1 (0.68) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL2643236 | 0.79 | PLK1 (0.68) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL21499127 | 0.79 | PLK1 (0.68) | PLK1HDAC6HDAC2HDAC8HPGD | |
| SCHEMBL710211 | 0.79 | PLK1 (0.68) | PLK1HDAC6HDAC2HDAC8HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |
| WO-2008096093-A1 | OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES | ARGENTA DISCOVERY LTD. (GB) | 2008-08-14 | — | — | WO | disclosed |