Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ASPH | Q12797 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410163 | 1.00 | HDAC8 (0.41) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL8201379 | 0.92 | HDAC1 (0.53) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL1411234 | 0.92 | NR1H4 (0.43) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL1411237 | 0.85 | MMP2 (0.40) | HDAC8HDAC6MMP2MMP9ANPEP | |
| SCHEMBL1411235 | 0.85 | MMP2 (0.40) | HDAC8HDAC6MMP2MMP9ANPEP | |
| SCHEMBL12810078 | 0.83 | MMP2 (0.39) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL19723055 | 0.80 | MMP2 (0.41) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL1403094 | 0.77 | HDAC1 (0.52) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL1403093 | 0.77 | HDAC1 (0.52) | HDAC8HDAC6HDAC4HDAC3HDAC1 | |
| SCHEMBL1491497 | 0.77 | MMP2 (0.44) | MMP2MMP9ANPEPLTA4HLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |
| US-9725407-B2 | HDAC inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-08-08 | — | — | US | disclosed |
| US-20160137594-A1 | HDAC INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2016-05-19 | — | — | US | disclosed |
| US-9273003-B2 | Methods of treating lymphoma and rheumatoid arthritis with cyclopentyl (2S)-cyclohexyl[({6-[3-(hydroxyamino)-3-oxopropyl]pyridin-3-yl}methyl)amino]acetate | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-03-01 | — | — | US | disclosed |
| US-20140323531-A1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2014-10-30 | — | — | US | disclosed |
| US-8637547-B2 | Compounds which inhibit members of the histone deacetylase family of enzymes and their use in the treatment of cell proliferative diseases | CHROMA THERAPEUTICS LTD. (GB) | 2014-01-28 | — | — | US | disclosed |
| US-20130197042-A1 | HDAC INHIBITORS | CHROMA THERAPEUTCS, LTD | 2013-08-01 | — | — | US | disclosed |
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |
| US-20100010010-A1 | HDAC INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2010-01-14 | — | — | US | disclosed |
| EP-2069291-A1 | HDAC INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008040934-A1 | HDAC INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323531-A1 | HDAC INHIBITORS | HDAC1, HDAC3, HDAC2 | HDAC8 7/4885HDAC6 10/4885HDAC4 6/4885 |
| US-20100010010-A1 | HDAC INHIBITORS | HDAC1, HDAC3, HDAC2 | HDAC8 7/4885HDAC6 10/4885HDAC4 6/4885 |
| US-20160137594-A1 | HDAC INHIBITORS | HDAC1, HDAC11, HDAC2 | HDAC8 8/4885HDAC6 11/4885HDAC4 4/4885 |
| US-20130197042-A1 | HDAC INHIBITORS | HDAC1, HDAC3, HDAC2 | HDAC8 7/4885HDAC6 10/4885HDAC4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.