Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | LAP3 | P28838 | 1/20 | 0.40 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411237 | 1.00 | MMP2 (0.40) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1410165 | 0.85 | HDAC8 (0.41) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1410163 | 0.85 | HDAC8 (0.41) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1411234 | 0.84 | NR1H4 (0.43) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL8201379 | 0.82 | HDAC1 (0.53) | HDAC8HDAC6 | |
| SCHEMBL396101 | 0.77 | AKR1C3 (0.49) | HDAC8HDAC6AKR1C3ALDH1A1 | |
| SCHEMBL396102 | 0.77 | AKR1C3 (0.49) | HDAC8HDAC6AKR1C3ALDH1A1 | |
| SCHEMBL12810078 | 0.76 | MMP2 (0.39) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491497 | 0.75 | MMP2 (0.44) | MMP2MMP9ANPEPLTA4HLAP3 | |
| SCHEMBL1491501 | 0.75 | MMP2 (0.44) | MMP2MMP9ANPEPLTA4HLAP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |