Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887377 | 0.91 | POLB (0.43) | POLBKDM4ETDP1MAPK1SMN1; SMN2 | |
| SCHEMBL14103274 | 0.84 | ALDH1A1 (0.40) | POLBKDM4ETDP1MAPK1SMN1; SMN2 | |
| SCHEMBL4886327 | 0.83 | POLB (0.46) | POLBKDM4ETDP1MAPK1SMN1; SMN2 | |
| SCHEMBL14102808 | 0.81 | MAPK1 (0.42) | POLBKDM4ETDP1MAPK1ALDH1A1 | |
| SCHEMBL14103272 | 0.79 | KDM4E (0.41) | POLBKDM4ETDP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14103623 | 0.77 | KDM4E (0.44) | POLBKDM4ESMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL14103273 | 0.76 | HTT (0.44) | POLBKDM4ESMN1; SMN2ALDH1A1THRB | |
| SCHEMBL4886249 | 0.76 | POLB (0.41) | POLBKDM4ETDP1MAPK1SMN1; SMN2 | |
| SCHEMBL4883942 | 0.76 | POLB (0.47) | POLBKDM4ETDP1MAPK1SMN1; SMN2 | |
| SCHEMBL14102820 | 0.76 | LMNA (0.39) | KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008098859-A1 | HCV POLYMERASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-21 | — | — | WO | disclosed |