Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783849 | 0.87 | MAPT (0.49) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL14105450 | 0.87 | ABCG2 (0.57) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL4740912 | 0.85 | ABCG2 (0.35) | ABCG2MAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4574102 | 0.82 | MAPT (0.50) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL4575030 | 0.81 | KDM4E (0.44) | MAPTL3MBTL1HTTCYP1A2CYP3A4 | |
| SCHEMBL4740942 | 0.80 | PTGS1 (0.46) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL4740291 | 0.80 | PTGS1 (0.46) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL14104181 | 0.80 | RXFP1 (0.55) | ABCG2MAPTL3MBTL1HTTCYP1A2 | |
| SCHEMBL11990374 | 0.80 | PRKCI (0.45) | MAPTL3MBTL1HTTCYP1A2CYP3A4 | |
| SCHEMBL9881228 | 0.80 | PRKCI (0.43) | MAPTL3MBTL1HTTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |