Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740291 | 1.00 | PTGS1 (0.46) | PTGS1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL14104181 | 0.88 | RXFP1 (0.55) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4783849 | 0.88 | MAPT (0.49) | KDM4ECYP1A2CYP3A4CYP2C19RXFP1 | |
| SCHEMBL4575030 | 0.87 | KDM4E (0.44) | KDM4ECYP1A2CYP3A4CYP2C19RXFP1 | |
| SCHEMBL4740295 | 0.84 | PTGS1 (0.40) | PTGS1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL14104172 | 0.84 | ABCG2 (0.49) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4738769 | 0.84 | MAPK1 (0.46) | PTGS1KDM4ECYP2C19HTTCYP2C9 | |
| SCHEMBL9881243 | 0.84 | MAPT (0.52) | KDM4ECYP1A2CYP3A4CYP2C19RXFP1 | |
| SCHEMBL14103882 | 0.81 | CYP1A2 (0.43) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4574102 | 0.81 | MAPT (0.50) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |