Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783849 | 0.88 | MAPT (0.49) | MAPTNPSR1POLBABCG2PDE4A | |
| SCHEMBL4575030 | 0.86 | KDM4E (0.44) | MAPTNPSR1POLBCYP19A1PDE4A | |
| SCHEMBL14103758 | 0.82 | ABCG2 (0.43) | MAPTABCG2L3MBTL1GAAKMT2A | |
| SCHEMBL14104181 | 0.81 | RXFP1 (0.55) | MAPTNPSR1POLBABCG2L3MBTL1 | |
| SCHEMBL4740291 | 0.81 | PTGS1 (0.46) | MAPTNPSR1ABCG2L3MBTL1GAA | |
| SCHEMBL4740942 | 0.81 | PTGS1 (0.46) | MAPTNPSR1ABCG2L3MBTL1GAA | |
| SCHEMBL11990374 | 0.79 | PRKCI (0.45) | MAPTL3MBTL1GAACYP1A2CYP3A4 | |
| SCHEMBL9881228 | 0.79 | PRKCI (0.43) | MAPTCYP11B2CYP11B1L3MBTL1GAA | |
| SCHEMBL14104447 | 0.77 | MAPT (0.43) | MAPTCYP11B1L3MBTL1GAAKMT2A | |
| SCHEMBL11891893 | 0.76 | MAPT (0.49) | MAPTNPSR1POLBABCG2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |