Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9881238 | 0.83 | HRH2 (0.45) | JAK3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14104444 | 0.74 | PIK3CA (0.42) | NPC1KDR | |
| SCHEMBL9881247 | 0.74 | SCN7A (0.43) | ACHEESR1KDR | |
| SCHEMBL4740938 | 0.73 | CXCR1 (0.40) | JAK3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14103896 | 0.71 | CYP4F2 (0.42) | JAK3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3029741 | 0.69 | SYK (0.56) | JAK3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4552729 | 0.66 | CASP3 (0.58) | NPC1RAB9AACHE | |
| SCHEMBL11898739 | 0.66 | NPC1 (0.97) | NPC1RAB9ALTA4HESR1KDR | |
| SCHEMBL14103890 | 0.65 | ABCG2 (0.36) | — | |
| SCHEMBL19560190 | 0.65 | LTA4H (0.67) | NPC1RAB9ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |