Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012912 | 0.83 | TRPV1 (0.58) | TRPV1ABCB1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL1013567 | 0.83 | TRPV1 (0.58) | TRPV1ABCB1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL13868105 | 0.74 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL21101485 | 0.73 | ALDH1A1 (0.58) | TRPV1ABCB1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL1011814 | 0.73 | TRPV1 (0.48) | TRPV1ALDH1A1CD274MEN1KMT2A | |
| SCHEMBL3072828 | 0.73 | ALDH1A1 (0.58) | TRPV1ALDH1A1P2RY14NOTUMMEN1 | |
| SCHEMBL29697303 | 0.73 | ALDH1A1 (0.58) | TRPV1ALDH1A1P2RY14NOTUMMEN1 | |
| SCHEMBL1015927 | 0.72 | TRPV1 (0.55) | TRPV1ALDH1A1 | |
| SCHEMBL1013062 | 0.71 | TRPV1 (0.54) | TRPV1CYP1A2 | |
| SCHEMBL24703329 | 0.71 | TRPV1 (0.67) | TRPV1ABCG2ALDH1A1P2RY14NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396831-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-07-08 | — | — | US | disclosed |