Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.42 |
| ▸ | RELA | Q04206 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14112654 | 1.00 | AQP1 (0.50) | AQP1NFKB1NFKB2RELAHTR1A | |
| SCHEMBL4621838 | 1.00 | AQP1 (0.50) | AQP1NFKB1NFKB2RELAHTR1A | |
| Hydrochloric Acid SCHEMBL4622653 | 0.99 | AQP1 (0.49) | AQP1NFKB1NFKB2RELAHTR1A | |
| Hydrochloric Acid SCHEMBL4621888 | 0.99 | AQP1 (0.49) | AQP1NFKB1NFKB2RELAHTR1A | |
| Hydrochloric Acid SCHEMBL4622690 | 0.99 | AQP1 (0.49) | AQP1NFKB1NFKB2RELAHTR1A | |
| SCHEMBL4622511 | 0.90 | AQP1 (0.59) | AQP1NFKB1NFKB2RELADRD2 | |
| Hydrochloric Acid SCHEMBL4622531 | 0.89 | AQP1 (0.58) | AQP1NFKB1NFKB2RELADRD2 | |
| SCHEMBL14112656 | 0.88 | AQP1 (0.48) | AQP1NFKB1NFKB2RELADRD2 | |
| SCHEMBL14112665 | 0.88 | AQP1 (0.59) | AQP1NFKB1NFKB2RELAHTR1A | |
| SCHEMBL4619713 | 0.88 | AQP1 (0.48) | AQP1NFKB1NFKB2RELADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-07-31 | — | — | US | disclosed |
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-07-31 | — | — | US | disclosed |
| US-7365095-B2 | Chromane and chromene derivatives and uses thereof | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365095-B2 | Chromane and chromene derivatives and uses thereof | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | HTR1A, HTR2C, CHRM1 | AQP1 3318/4885NFKB1 4732/4885NFKB2 4292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.