Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9419196 | 0.79 | MEN1 (0.55) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL9419174 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL9135996 | 0.79 | TDP1 (0.44) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL10048292 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2LMNAKMT2AALDH1A1NPC1 | |
| SCHEMBL10965817 | 0.77 | MEN1 (0.42) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL11815620 | 0.75 | ALDH1A1 (0.47) | SMN1; SMN2CYP3A4MEN1KMT2ATSHR | |
| SCHEMBL29940658 | 0.75 | MAPT (0.47) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL21678069 | 0.73 | BAZ2B (0.43) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL10282142 | 0.73 | ALDH1A1 (0.48) | SMN1; SMN2MEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL997530 | 0.73 | TSHR (0.49) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670770-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEROF AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1670790-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |