Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 16/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.54 |
| ▸ | TSHR | P16473 | 11/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.52 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14132888 | 0.86 | FAAH (0.48) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL11786092 | 0.75 | CYP1A2 (0.56) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL14132465 | 0.75 | MAPT (0.57) | CYP1A2CYP3A4CYP2C19LMNAALDH1A1 | |
| SCHEMBL11783584 | 0.75 | FAAH (0.53) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| Hydrochloric Acid SCHEMBL11784883 | 0.74 | FAAH (0.52) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL18902711 | 0.73 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL27804390 | 0.71 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| Hydrochloric Acid SCHEMBL11786048 | 0.71 | CYP1A2 (0.83) | CYP1A2CYP3A4CYP2D6CLK4CYP2C19 | |
| SCHEMBL5759347 | 0.71 | MAP4K4 (0.51) | MAPK1MAP4K4 | |
| SCHEMBL5477065 | 0.70 | MAP4K4 (0.42) | CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | THE TRUSTEES OF DARTMOUTH COLLEGE | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302581-A1 | Methods and Compositions for the Treatment of RAS Associated Disorders | NRAS, HRAS, KRAS | CYP1A2 4728/4885CYP3A4 4876/4885CYP2D6 4776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.