⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252392 | 0.81 | — | — | |
| SCHEMBL12275635 | 0.69 | — | — | |
| SCHEMBL983496 | 0.65 | — | — | |
| SCHEMBL4269064 | 0.62 | — | — | |
| SCHEMBL6573284 | 0.62 | — | — | |
| SCHEMBL1834485 | 0.59 | — | — | |
| Formaldehyde SCHEMBL8899421 | 0.59 | TRPA1 (0.31) | — | |
| SCHEMBL4725494 | 0.54 | — | — | |
| SCHEMBL2774259 | 0.54 | — | — | |
| SCHEMBL11804916 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-58018369-A | — | — | None | — | — | JP | disclosed |
| EP-1328510-B1 | (E)-N-HYDROXY-3-(3-SULFAMOYL-PHENYL)-ACRYLAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE | TOPOTARGET UK LTD (GB) | 2013-11-20 | — | — | EP | disclosed |
| EP-2292593-A2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TopoTarget UK Limited (GB) | 2011-03-09 | — | — | EP | disclosed |
| US-7407988-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-7183298-B2 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2007-02-27 | — | — | US | disclosed |
| US-20070004806-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPOTARGET UK LIMITED (GB) | 2007-01-04 | — | — | US | disclosed |
| US-20050107445-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | PROLIFIX LIMITED (GB) | 2005-05-19 | — | — | US | disclosed |
| US-20050085515-A1 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors | TOPO TARGET UK LIMITED, (GB) | 2005-04-21 | — | — | US | disclosed |
| EP-1328510-A2 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LTD. (GB) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002030879-A2 | CARBAMIC ACID COMPOUNDS COMPRISING A SULFONAMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LIMITED (GB) | 2002-04-18 | — | — | WO | disclosed |
| EP-0046658-B1 | PRODUCTION OF TRIAZOLYLVINYL KETONES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-10-24 | — | — | EP | disclosed |
| US-4379921-A | FROM CHLOROBENZALPINACOLONES AND 1,2,4-TRIAZOLE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-04-12 | — | — | US | disclosed |
| JP-S5818369-A | PREPARATION OF BISTRIAZOLYL KETONIC COMPOUND | SUMITOMO CHEM CO LTD | 1983-02-02 | — | — | JP | disclosed |
| EP-0046658-A2 | Production of triazolylvinyl ketones | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-03-03 | — | — | EP | disclosed |