Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.68 |
| ▸ | STK4 | Q13043 | 2/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12094750 | 0.90 | EGFR (0.67) | EGFRERBB2SRC | |
| SCHEMBL12094777 | 0.90 | EGFR (0.59) | EGFRERBB2SRC | |
| SCHEMBL2574073 | 0.90 | EGFR (0.85) | EGFRERBB2STK4SRC | |
| Hydrochloric Acid SCHEMBL2052299 | 0.89 | EGFR (0.84) | EGFRERBB2STK4SRC | |
| SCHEMBL12641780 | 0.88 | EGFR (0.51) | EGFRERBB2STK4SRC | |
| SCHEMBL28547159 | 0.86 | STK4 (0.70) | EGFRERBB2STK4SRC | |
| SCHEMBL20584416 | 0.83 | EGFR (0.71) | EGFRERBB2STK4SRC | |
| SCHEMBL31661487 | 0.83 | MAP2K1 (0.73) | EGFRERBB2STK4SRC | |
| SCHEMBL22419601 | 0.82 | EGFR (0.71) | EGFRERBB2STK4SRC | |
| SCHEMBL31661555 | 0.82 | STK4 (0.72) | EGFRERBB2STK4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161575-A1 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile | WYETH (US) | 2008-07-03 | — | — | US | disclosed |
| US-7365203-B2 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161575-A1 | Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile | QPCT, CYP3A4, CPNE4 | EGFR 2586/4885ERBB2 1303/4885STK4 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.