Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.71 |
| ▸ | GAK | O14976 | 2/20 | 0.63 |
| ▸ | STK4 | Q13043 | 5/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2131741 | 0.94 | EGFR (0.72) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL29670932 | 0.94 | EGFR (0.72) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL30132269 | 0.94 | EGFR (0.72) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL1897571 | 0.89 | EGFR (0.85) | EGFRERBB2GAKSTK4 | |
| SCHEMBL20584416 | 0.89 | EGFR (0.71) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL2943166 | 0.86 | EGFR (0.85) | EGFRERBB2GAKSRC | |
| SCHEMBL28046215 | 0.84 | STK4 (0.61) | EGFRERBB2STK4 | |
| SCHEMBL3593063 | 0.84 | EGFR (0.86) | EGFRERBB2GAKSRC | |
| SCHEMBL28547159 | 0.84 | STK4 (0.70) | EGFRERBB2STK4SRC | |
| SCHEMBL22419673 | 0.83 | STK4 (0.84) | EGFRERBB2STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774068-B2 | Composition and methods for inhibiting mammalian sterile 20-like kinase 1 | TESK2, TESK1, PRKACB | EGFR 3953/4885ERBB2 3266/4885GAK 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.