Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 5/20 | 0.70 |
| ▸ | SRC | P12931 | 6/20 | 0.70 |
| ▸ | EGFR | P00533 | 6/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.67 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574073 | 0.89 | EGFR (0.85) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL20584416 | 0.89 | EGFR (0.71) | STK4SRCEGFRERBB2 | |
| SCHEMBL31661487 | 0.89 | MAP2K1 (0.73) | STK4SRCEGFRERBB2MAP2K1 | |
| Hydrochloric Acid SCHEMBL2052299 | 0.88 | EGFR (0.84) | STK4SRCEGFRERBB2MAP2K1 | |
| SCHEMBL31661555 | 0.87 | STK4 (0.72) | STK4SRCEGFRERBB2 | |
| SCHEMBL14135437 | 0.86 | EGFR (0.68) | STK4SRCEGFRERBB2 | |
| SCHEMBL15320486 | 0.86 | MAP2K1 (0.72) | STK4EGFRERBB2MAP2K1 | |
| SCHEMBL22419601 | 0.84 | EGFR (0.71) | STK4SRCEGFRERBB2 | |
| SCHEMBL28547991 | 0.84 | EGFR (0.64) | STK4EGFRERBB2MAP2K1 | |
| SCHEMBL27974765 | 0.83 | EGFR (0.62) | STK4SRCEGFRERBB2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759583-B | Quinoline derivative containing furyl and preparation method and application thereof | 河南省医药科学研究院 | 2022-10-11 | — | — | CN | disclosed |
| CN-112694439-B | Phenyl acrylamide quinoline derivative and preparation method and application thereof | 河南省医药科学研究院 | 2022-08-30 | — | — | CN | disclosed |
| CN-112625025-B | Pyridyl substituted quinoline derivative and its prepn and use | 河南省医药科学研究院 | 2022-03-29 | — | — | CN | disclosed |
| CN-112759583-A | Quinoline derivative containing furyl and preparation method and application thereof | 河南省医药科学研究院 | 2021-05-07 | — | — | CN | disclosed |
| CN-112694439-A | Phenyl acrylamide quinoline derivative and preparation method and application thereof | 河南省医药科学研究院 | 2021-04-23 | — | — | CN | disclosed |
| CN-112625025-A | Pyridyl substituted quinoline derivative and its prepn and use | 河南省医药科学研究院 | 2021-04-09 | — | — | CN | disclosed |