Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095615 | 0.82 | L3MBTL1 (0.66) | PTPN1L3MBTL1GAAMAPT | |
| SCHEMBL7954014 | 0.81 | PTPN1 (0.58) | PTPN1POLBTSHRKMT2AL3MBTL1 | |
| SCHEMBL4488799 | 0.77 | HSD17B10 (0.59) | POLBKMT2AL3MBTL1MEN1HSD17B10 | |
| SCHEMBL29406212 | 0.77 | PTPN1 (0.75) | PTPN1POLBTSHRKMT2AMEN1 | |
| SCHEMBL23924441 | 0.77 | PTPN1 (0.75) | PTPN1POLBTSHRKMT2AMEN1 | |
| SCHEMBL3078899 | 0.76 | TSHR (0.53) | PTPN1TSHRKMT2AL3MBTL1MEN1 | |
| SCHEMBL7956544 | 0.75 | KMT2A (0.72) | PTPN1POLBTSHRKMT2AL3MBTL1 | |
| SCHEMBL6838359 | 0.75 | KMT2A (0.68) | PTPN1POLBTSHRKMT2AL3MBTL1 | |
| SCHEMBL23943618 | 0.75 | KMT2A (0.68) | PTPN1POLBTSHRKMT2AL3MBTL1 | |
| SCHEMBL4480002 | 0.74 | CYP1A2 (0.64) | KMT2AMEN1GAAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399452-B2 | Anticancer agents; antiproliferative agenst; antiprotozoa agents | METHYLGENE INC. (CA) | 2013-03-19 | — | — | US | disclosed |
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207590-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC11 | PTPN1 3867/4885POLB 694/4885TSHR 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.