Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944942 | 0.83 | GABBR2 (0.53) | ATMALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL14327771 | 0.81 | MEN1 (0.59) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL28007920 | 0.79 | ALDH1A1 (0.55) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17767291 | 0.78 | KMT2A (0.57) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17767290 | 0.78 | KMT2A (0.57) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3077522 | 0.77 | TSHR (0.59) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7050949 | 0.77 | TSHR (0.59) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6200667 | 0.77 | TSHR (0.63) | TSHRATMKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL4943739 | 0.76 | NAALAD2 (0.46) | TSHRSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL27197678 | 0.76 | TSHR (0.58) | TSHRATMKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012160447-A1 | 3, 5 -DIPHENYL- SUBSTITUTED PYRAZOLINES FOR THE TREATMENT OF CANCER, PROLIFERATIVE, INFLAMMATORY OR AUTOIMMUNE DISEASES | DYNAMIX PHARMACEUTICALS LTD. (IL) | 2012-11-29 | — | — | WO | disclosed |