Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6125250 | 0.90 | ADRB2 (0.72) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL2707478 | 0.87 | ADRB2 (0.66) | ADRB2TSHRMAPK1ADRA2AHTR2C | |
| SCHEMBL6125222 | 0.81 | ADRB2 (0.72) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL13135656 | 0.80 | ADRB2 (0.70) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL2708405 | 0.77 | ADRB2 (0.72) | ADRB2TSHRKMT2AADRA2AHTR2C | |
| SCHEMBL13135663 | 0.77 | KDM4E (0.64) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL6125303 | 0.76 | ADRB2 (1.00) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL14136364 | 0.76 | ADRB2 (0.77) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL10268283 | 0.75 | ADRB2 (0.75) | ADRB2KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL13135657 | 0.75 | ADRB2 (0.75) | ADRB2KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950199-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-07-30 | — | — | EP | disclosed |
| EP-1930319-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-06-11 | — | — | EP | disclosed |