Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.64 |
| ▸ | HTR3B | O95264 | 2/20 | 0.64 |
| ▸ | HTR3A | P46098 | 2/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.64 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23657801 | 0.83 | TLR7 (0.72) | TLR7CYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL2710555 | 0.83 | TLR7 (0.76) | TLR7CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL4085139 | 0.79 | RAB9A (0.78) | CYP1A2CYP3A4CYP2D6MAPK1HRH4 | |
| SCHEMBL5320912 | 0.78 | HTR3B (0.69) | CYP1A2CYP3A4CYP2D6MAPK1HTR3E | |
| SCHEMBL13125713 | 0.78 | HRH4 (1.00) | CYP1A2CYP3A4CYP2D6MAPK1HTR3E | |
| Hydrochloric Acid SCHEMBL11740107 | 0.77 | HTR3B (0.68) | CYP1A2CYP3A4CYP2D6MAPK1HTR3E | |
| SCHEMBL6125247 | 0.77 | TSHR (0.84) | CYP1A2CYP3A4CYP2D6MAPK1HTR3E | |
| SCHEMBL4085081 | 0.75 | HTR3E (0.66) | CYP1A2CYP3A4CYP2D6MAPK1HTR3E | |
| SCHEMBL27866870 | 0.75 | HTR3E (0.66) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15963530 | 0.75 | TLR7 (0.59) | TLR7CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950199-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-07-30 | — | — | EP | disclosed |
| EP-1930319-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-06-11 | — | — | EP | disclosed |