Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 13/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586480 | 0.79 | PKM (0.57) | BRAFPKM | |
| SCHEMBL14138605 | 0.72 | LMNA (0.41) | TDP1BRAFSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL26122356 | 0.68 | MAPT (0.62) | TDP1POLBMAPTSMN1; SMN2KDM4E | |
| SCHEMBL14138530 | 0.66 | CYP3A4 (0.40) | POLBMAPTKDM4EALDH1A1CYP2C9 | |
| SCHEMBL3595328 | 0.66 | PKM (0.62) | BRAFPKM | |
| SCHEMBL31252556 | 0.64 | NAMPT (0.45) | POLBMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL26126882 | 0.64 | NAMPT (0.45) | POLBMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL26126245 | 0.64 | MAPT (0.53) | TDP1POLBMAPTSMN1; SMN2KDM4E | |
| SCHEMBL3593086 | 0.59 | BRAF (0.60) | BRAFPKM | |
| SCHEMBL30713090 | 0.59 | MAPT (0.76) | TDP1POLBMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |