Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TCF4 | P15884 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14138580 | 0.85 | CACNA1H (0.43) | BRAFALDH1A1 | |
| SCHEMBL3581353 | 0.80 | BRAF (0.58) | BRAF | |
| SCHEMBL14138576 | 0.80 | HPGD (0.43) | MAPTHTTBRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL14138848 | 0.79 | CACNA1H (0.46) | NPSR1ALDH1A1 | |
| SCHEMBL14138888 | 0.79 | HIF1A (0.39) | L3MBTL1MAPTBRAF | |
| SCHEMBL14138703 | 0.76 | ALDH1A1 (0.40) | L3MBTL1NPSR1BRAFALDH1A1 | |
| SCHEMBL14138522 | 0.76 | BRAF (0.42) | BRAF | |
| SCHEMBL14138708 | 0.75 | PKM (0.38) | BRAFHDAC3 | |
| SCHEMBL14138535 | 0.75 | PRKCI (0.38) | BRAFALDH1A1 | |
| SCHEMBL14138527 | 0.75 | PKM (0.36) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |