Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 4/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414118 | 0.96 | LMNA (0.43) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL3259690 | 0.96 | LMNA (0.43) | LMNATP53CA1CYP2D6SPHK1 | |
| Potassium Ion SCHEMBL18077253 | 0.96 | LMNA (0.43) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL7469371 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL18986934 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 | |
| Potassium Ion SCHEMBL18062300 | 0.94 | LMNA (0.42) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL8824223 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 | |
| Potassium Ion SCHEMBL8824224 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL185844 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 | |
| SCHEMBL135873 | 0.94 | LMNA (0.47) | LMNATP53CA1CYP2D6SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195405-B1 | MILD ACYL ISETHIONATE TOILET BAR COMPOSITION | UNILEVER PLC (GB) | 2011-03-09 | — | — | EP | disclosed |
| EP-2195405-A1 | MILD ACYL ISETHIONATE TOILET BAR COMPOSITION | Unilever PLC (GB) | 2010-06-16 | — | — | EP | disclosed |
| US-7737096-B2 | Mild acyl isethionate toilet bar composition | UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. (US) | 2010-06-15 | — | — | US | disclosed |
| WO-2009043716-A1 | MILD ACYL ISETHIONATE TOILET BAR COMPOSITION | UNILEVER PLC (GB) | 2009-04-09 | — | — | WO | disclosed |
| US-20080058237-A1 | Mild acyl isethionate toilet bar composition | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO | 2008-03-06 | — | — | US | disclosed |