Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.59 |
| ▸ | PLG | P00747 | 1/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19070659 | 0.83 | F2 (0.56) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL12326742 | 0.81 | PBRM1 (0.57) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL771139 | 0.79 | F2 (0.52) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL28216252 | 0.79 | PBRM1 (0.55) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL16396188 | 0.77 | PBRM1 (0.59) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL3147361 | 0.77 | F2 (0.50) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL31650871 | 0.76 | F2 (0.59) | F2PRSS1PRSS2PRSS3PLG | |
| 3-Aminobenzamide SCHEMBL16070 | 0.76 | PBRM1 (0.63) | F2PRSS1PRSS2PRSS3PLG | |
| SCHEMBL14515478 | 0.76 | PARP1 (0.61) | CYP3A4LMNAALDH1A1TDP1CA1 | |
| SCHEMBL231914 | 0.76 | PRSS1 (0.95) | F2PRSS1PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216966-B2 | Compounds for Alzheimer's disease | Manfredi, John (US) | 2015-12-22 | — | — | US | disclosed |
| EP-1944305-A1 | Quinoline derivatives as phosphodiesterase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-07-16 | — | — | EP | disclosed |