Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278826 | 1.00 | GPR119 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL4280153 | 0.94 | CHEK2 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL4280149 | 0.94 | CHEK2 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL22278188 | 0.88 | GPR119 (0.52) | GPR119USP30PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22278189 | 0.88 | GPR119 (0.52) | GPR119USP30PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22278273 | 0.88 | GPR119 (0.52) | GPR119USP30PIK3CDPIK3CAPIK3CB | |
| SCHEMBL31233745 | 0.88 | USP30 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL27077000 | 0.88 | USP30 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL29116484 | 0.88 | USP30 (0.45) | GPR119ALDH1A1LMNAMAPTUSP30 | |
| SCHEMBL23213645 | 0.88 | ALDH1A1 (0.44) | GPR119ALDH1A1LMNAMAPTUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7399866-B2 | Compounds, compositions, and methods | CYTOKINETICS, INC. (US) | 2008-07-15 | — | — | US | disclosed |