Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | CCL5 | P13501 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13411074 | 0.84 | CCL5 (0.36) | OPRM1OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13114320 | 0.84 | CCL5 (0.36) | OPRM1OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13294139 | 0.84 | CCL5 (0.36) | OPRM1OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13411075 | 0.77 | KDM4E (0.40) | OPRM1OPRD1KCNH2OPRK1CCL5 | |
| SCHEMBL13481967 | 0.77 | CCR5 (0.37) | OPRM1OPRD1SLC6A2KCNH2CCL5 | |
| SCHEMBL13481505 | 0.77 | CCR5 (0.37) | OPRM1OPRD1SLC6A2KCNH2CCL5 | |
| SCHEMBL13481535 | 0.77 | CCR5 (0.37) | OPRM1OPRD1SLC6A2KCNH2CCL5 | |
| SCHEMBL13481971 | 0.77 | CCR5 (0.37) | OPRM1OPRD1SLC6A2KCNH2CCL5 | |
| SCHEMBL13294181 | 0.75 | CCL5 (0.40) | OPRM1OPRD1KCNH2OPRK1HTR6 | |
| SCHEMBL493622 | 0.75 | CACNA2D1 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079284-A1 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS | SCHERING CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |