Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13561015 | 0.91 | MEN1 (0.66) | MEN1KMT2AALDH1A1SMN1; SMN2TRPV1 | |
| SCHEMBL13576512 | 0.90 | KMT2A (0.79) | MEN1KMT2AALDH1A1SMN1; SMN2TRPV1 | |
| SCHEMBL14148658 | 0.87 | LMNA (0.76) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14148621 | 0.85 | ALDH1A1 (0.72) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14148651 | 0.81 | KMT2A (0.57) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL16038025 | 0.79 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL977661 | 0.78 | CDC7 (0.70) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL14148629 | 0.77 | KDR (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2TRPV1 | |
| SCHEMBL17317816 | 0.76 | IRAK4 (0.67) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL14148639 | 0.76 | TSHR (0.61) | MEN1KMT2AALDH1A1SMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |