Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.50 |
| ▸ | CCR8 | P51685 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 6/20 | 0.49 |
| ▸ | ALPL | P05186 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11651772 | 0.87 | KDM4E (0.47) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL7264629 | 0.85 | KDM4E (0.49) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL5196242 | 0.85 | KDM4E (0.47) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL776048 | 0.81 | KDM4E (0.67) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL1921676 | 0.81 | NOS2 (0.44) | KDM4EALOX15L3MBTL1TDP1HSP90AA1 | |
| SCHEMBL12824407 | 0.79 | KDM4E (0.71) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL30835039 | 0.78 | KDM4E (0.63) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL580823 | 0.78 | KDM4E (0.75) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL27754726 | 0.78 | HSP90AA1 (0.42) | KDM4EHSP90AA1NOS3NOS1NOS2 | |
| SCHEMBL31268013 | 0.78 | KDM4E (0.75) | KDM4EALOX15L3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | claimed |
| US-11541041-B1 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2023-01-03 | — | — | US | claimed |
| EP-4719421-A1 | COMBINATION THERAPY COMPRISING KIT INHIBITORS FOR USE IN THE TREATMENT OF CANCER | IDRX, INC. (US) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024249855-A1 | COMBINATION THERAPY COMPRISING KIT INHIBITORS FOR USE IN THE TREATMENT OF CANCER | IDRX, INC. (US) | 2024-12-05 | — | — | WO | disclosed |
| CN-111032662-B | Compounds that interact with the RAS superfamily for the treatment of cancer, inflammatory diseases, RAS proteinopathies and fibrotic diseases | 尚医治疗有限责任公司 | 2024-10-15 | — | — | CN | disclosed |
| EP-4331679-A2 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | Shy Therapeutics LLC (US) | 2024-03-06 | — | — | EP | disclosed |
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| CN-113956238-B | Protein kinase inhibitor and preparation method and medical application thereof | 甘李药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20230149369-A1 | Compounds that Interact with the Ras Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease | SHY Therapeutics LLC (US) | 2023-05-18 | — | — | US | disclosed |
| US-20230149369-A1 | Compounds that Interact with the Ras Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease | SHY Therapeutics LLC (US) | 2023-05-18 | — | — | US | disclosed |
| EP-1254903-A1 | 4-Amino-2-(pyridin-2-yl)pyrimidine as microbicidal active substances | Ciba SC Holding AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| US-RE30024-E | ANTIALLERGENS | STERLING DRUG INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4118571-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4109092-A | FROM PYRIDINYL-CARBOXAMIDINE AND ALPHA-CHLOROACRYLONITRILE | STERLING DRUG INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-4086233-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4053475-A | ANTI-ALLERGIC AGENTS | STERLING DRUG INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4032523-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-4018770-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4008235-A | ANTIALLERGIC | STERLING DRUG INC. (US) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230149369-A1 | Compounds that Interact with the Ras Superfamily for the Treatment of Cancers, Inflammatory Diseases, Rasopathies, and Fibrotic Disease | HRAS, KRAS, NRAS | KDM4E 4215/4885ALOX15 2801/4885L3MBTL1 1677/4885 |
| US-11541041-B1 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease | HRAS, KRAS, NRAS | KDM4E 4215/4885ALOX15 2801/4885L3MBTL1 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.