Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NMT1 | P30419 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 2/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16508907 | 0.78 | TSHR (0.48) | TSHRMAPTNMT1LMNAHTT | |
| SCHEMBL8232738 | 0.77 | TSHR (0.45) | TSHRMAPTNMT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1472720 | 0.77 | TSHR (0.47) | TSHRMAPTNMT1LMNAHTT | |
| SCHEMBL3376273 | 0.75 | TSHR (0.44) | TSHRMAPTNMT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3069717 | 0.75 | KDM4E (0.53) | TSHRMAPTNMT1LMNASMN1; SMN2 | |
| SCHEMBL4895697 | 0.75 | TSHR (0.44) | TSHRMAPTNMT1SMN1; SMN2ALDH1A1 | |
| SCHEMBL347771 | 0.75 | TSHR (0.44) | TSHRMAPTNMT1LMNAALDH1A1 | |
| SCHEMBL14468543 | 0.73 | ALDH1A1 (0.48) | TSHRMAPTNMT1LMNAHTT | |
| Hydrochloric Acid SCHEMBL14759214 | 0.73 | KDM4E (0.51) | TSHRMAPTNMT1LMNAALDH1A1 | |
| SCHEMBL13290812 | 0.72 | ALDH1A1 (0.43) | TSHRMAPTNMT1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324174-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-12-04 | — | — | US | disclosed |