Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 10/20 | 0.40 |
| ▸ | FPR2 | P25090 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232738 | 0.80 | TSHR (0.45) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL4636620 | 0.79 | MCL1 (0.48) | PROKR1FPR2NMT1GAA | |
| SCHEMBL347771 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL3376273 | 0.78 | TSHR (0.44) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL3069717 | 0.78 | KDM4E (0.53) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| Hydrochloric Acid SCHEMBL14759214 | 0.77 | KDM4E (0.51) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL14468543 | 0.77 | ALDH1A1 (0.48) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL14149159 | 0.75 | TSHR (0.53) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL13726542 | 0.75 | TSHR (0.42) | TSHRALDH1A1NPSR1PROKR1FPR2 | |
| SCHEMBL13290812 | 0.75 | ALDH1A1 (0.43) | TSHRALDH1A1NPSR1PROKR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318933-A1 | 5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders | GLAXO GROUP LIMITED | 2008-12-25 | — | — | US | disclosed |
| CN-101072768-A | 5-sulfonyl-1-piperidinyl substituted indole derivatives as 5-ht6 receptor antagonists for the treatment of CNS disorders | GLAXO GROUP LTD (GB) | 2007-11-14 | — | — | CN | disclosed |
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318933-A1 | 5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders | HTR6, HTR5A, TPH1 | TSHR 246/4885ALDH1A1 1462/4885NPSR1 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.