Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15382055 | 0.78 | KIT (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL1582031 | 0.77 | KIT (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL12019737 | 0.77 | KIT (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL17480021 | 0.76 | KIT (0.42) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL19531691 | 0.74 | KDM5B (0.43) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL24333809 | 0.73 | KIT (0.40) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL21850226 | 0.73 | KIT (0.40) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL16424234 | 0.70 | F2 (0.40) | KITKDM5B | |
| SCHEMBL19539076 | 0.70 | JAK2 (0.39) | KITKDM5BJAK2JAK1TYK2 | |
| SCHEMBL16423979 | 0.69 | ALDH1A1 (0.42) | KITKDM5BMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008088881-A1 | KINASE INHIBITOR COMPOUNDS | XCOVERY, INC. (US) | 2008-07-24 | — | — | WO | disclosed |