Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 9/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10331954 | 0.89 | HPGD (0.61) | HPGDHRH3ALDH1A1KDM4EHTT | |
| SCHEMBL10331961 | 0.89 | ALDH1A1 (0.57) | HPGDALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL10332064 | 0.84 | MKNK1 (0.65) | PHGDHHPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL10332010 | 0.84 | ALDH1A1 (0.45) | HPGDALDH1A1HTTLMNASLC6A7 | |
| SCHEMBL12529439 | 0.83 | HPGD (0.51) | PHGDHHPGDMKNK1MKNK2ALDH1A1 | |
| SCHEMBL10331351 | 0.81 | HSP90AA1 (0.51) | PHGDHHPGDMKNK1MKNK2HRH3 | |
| SCHEMBL10331953 | 0.79 | GRIN2B (0.46) | HPGDALDH1A1HTTSLC6A7HSP90AA1 | |
| SCHEMBL17809708 | 0.79 | HPGD (0.60) | PHGDHHPGDHRH3ALDH1A1MAPT | |
| SCHEMBL12722423 | 0.77 | HPGD (0.77) | HPGDHRH3ALDH1A1MAPTKDM4E | |
| SCHEMBL309271 | 0.77 | HPGD (0.64) | PHGDHHPGDHRH3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171741-A1 | HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171741-A1 | HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | MAP3K1, MAP3K8, MAP3K20 | PHGDH 1057/4885HPGD 644/4885MKNK1 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.