Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603361 | 0.88 | POLB (0.46) | POLBNPC1CYP3A4MEN1KMT2A | |
| SCHEMBL16106219 | 0.87 | CTSD (0.44) | POLBNPC1CYP3A4MEN1KMT2A | |
| SCHEMBL1303020 | 0.83 | ALDH1A1 (0.46) | NPC1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL16106448 | 0.82 | KMT2A (0.49) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL16106449 | 0.82 | KMT2A (0.49) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL689245 | 0.81 | TPMT (0.51) | NPC1MEN1KMT2AALDH1A1HTT | |
| SCHEMBL1599294 | 0.81 | ALDH1A1 (0.48) | POLBNPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL4948393 | 0.81 | HPGD (0.38) | POLBNPC1CYP3A4MEN1KMT2A | |
| SCHEMBL4948604 | 0.81 | ALDH1A1 (0.43) | POLBNPC1CYP3A4MEN1KMT2A | |
| SCHEMBL1900976 | 0.80 | ALDH1A1 (0.45) | POLBNPC1CYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089034-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-07-24 | — | — | WO | disclosed |