Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | ESR1 | P03372 | 5/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14157131 | 0.92 | LMNA (0.62) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14156942 | 0.92 | LMNA (0.64) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14157000 | 0.83 | LMNA (0.56) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL3723950 | 0.79 | LMNA (0.76) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL12325802 | 0.79 | ESR1 (0.78) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL13856884 | 0.79 | LMNA (0.76) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL27225472 | 0.78 | LMNA (0.79) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14158220 | 0.77 | LMNA (0.77) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14156914 | 0.77 | LMNA (1.00) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14157022 | 0.76 | LMNA (0.71) | LMNAESR1ESR2TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170371-A1 | COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | N30 PHARMACEUTICALS, LLC (US) | 2012-12-13 | — | — | WO | disclosed |