Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.79 |
| ▸ | ESR1 | P03372 | 5/20 | 0.77 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.77 |
| ▸ | TTR | P02766 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14156914 | 0.88 | LMNA (1.00) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL13856884 | 0.88 | LMNA (0.76) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL12325802 | 0.88 | ESR1 (0.78) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL3723950 | 0.88 | LMNA (0.76) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14157022 | 0.85 | LMNA (0.71) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14157030 | 0.85 | LMNA (0.73) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL14158220 | 0.84 | LMNA (0.77) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL12156080 | 0.83 | TTR (1.00) | LMNAESR1ESR2TTRALDH1A1 | |
| SCHEMBL18550795 | 0.81 | ALDH1A1 (1.00) | LMNAESR1ESR2ALDH1A1KDM4E | |
| SCHEMBL14156942 | 0.80 | LMNA (0.64) | LMNAESR1ESR2TTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174649-A1 | CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2024-05-30 | — | — | US | disclosed |
| WO-2022165432-A1 | CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240174649-A1 | CULLIN-RING E3 UBIQUITIN LIGASE 4 INHIBITOR COMPOUNDS AND METHODS OF THEIR USE | CUL4A, CUL1, CUL3 | LMNA 2544/4885ESR1 1881/4885ESR2 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.