Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14121280 | 1.00 | HTR2C (0.41) | HTR2CKMOBCDIN3DHDAC4HDAC2 | |
| SCHEMBL20931702 | 1.00 | HTR2C (0.41) | HTR2CKMOBCDIN3DHDAC4HDAC2 | |
| Hydrochloric Acid SCHEMBL14157452 | 0.98 | HTR2C (0.42) | HTR2CKMOBCDIN3DHDAC4HDAC2 | |
| Hydrochloric Acid SCHEMBL14121999 | 0.98 | HTR2C (0.42) | HTR2CKMOBCDIN3DHDAC4HDAC2 | |
| Hydrochloric Acid SCHEMBL20916768 | 0.98 | HTR2C (0.42) | HTR2CKMOBCDIN3DHDAC4HDAC2 | |
| SCHEMBL5760911 | 0.87 | QDPR (0.47) | ADRA1ADRD2OPRM1 | |
| SCHEMBL15566600 | 0.84 | HTR2C (0.43) | HTR2CKMOHDAC4HDAC2HDAC8 | |
| SCHEMBL9483230 | 0.82 | HTR2C (0.47) | HTR2CDRD2 | |
| SCHEMBL31085235 | 0.81 | LMNA (0.44) | HTR2CKMOHDAC4HDAC2HDAC8 | |
| SCHEMBL16961065 | 0.81 | HTR2C (0.41) | HTR2CKMOBCDIN3DHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-113727758-A | Bicyclic heterocyclic compounds and use thereof | 锐新医药公司 | 2021-11-30 | — | — | CN | disclosed |
| WO-2020200161-A1 | SALT OF INDAZOLYL-CONTAINING TRICYCLIC DERIVATIVE AND CRYSTAL FORM THEREOF | 上海翰森生物医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |
| WO-2019076336-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏豪森药业集团有限公司 | 2019-04-25 | — | — | WO | disclosed |
| WO-2012170561-A1 | N-BENZYLINDOLE MODULATORS OF PPARG | THE SCRIPPS RESEARCH INSTITUTE (T.S.R.I.) (US) | 2012-12-13 | — | — | WO | disclosed |