SCHEMBL14159643

SCHEMBL14159643

COc1ccc(F)cc1C(C)(CC(C)(O)Cn1ncc2ccccc21)C(F)(F)F

nearest known ligand 0.52

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 19/20 0.52
NR3C2 P08235 14/20 0.52
PGR P06401 6/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL293070 0.87 NR3C1 (0.65) NR3C1NR3C2PGR
SCHEMBL1932861 0.79 NR3C1 (0.52) NR3C1NR3C2PGR
SCHEMBL27778227 0.77 NR3C1 (0.55) NR3C1NR3C2PGR
SCHEMBL4426931 0.76 NR3C1 (0.57) NR3C1NR3C2PGR
SCHEMBL4479481 0.75 NR3C1 (0.71) NR3C1NR3C2PGR
SCHEMBL3789054 0.74 NR3C1 (0.47) NR3C1NR3C2PGR
SCHEMBL4471868 0.74 NR3C1 (0.56) NR3C1NR3C2PGR
SCHEMBL6916338 0.73 NR3C1 (0.74) NR3C1NR3C2PGR
SCHEMBL6912427 0.72 NR3C1 (0.77) NR3C1NR3C2PGR
SCHEMBL3654089 0.71 NR3C1 (0.57) NR3C1NR3C2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012170175-A1 COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING INFLAMMATORY PAIN BAUSCH & LOMB INCORPORATED (US) 2012-12-13 WO disclosed