Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693786 | 1.00 | P2RX7 (0.55) | P2RX7MDM2TGFBR1ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL10445426 | 0.91 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10445425 | 0.91 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL10445424 | 0.91 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1LMNA | |
| SCHEMBL14160076 | 0.86 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1 | |
| SCHEMBL4696923 | 0.85 | TGFBR1 (0.58) | P2RX7MDM2TGFBR1ALDH1A1MEN1 | |
| SCHEMBL4693172 | 0.85 | P2RX7 (0.55) | P2RX7MDM2TGFBR1ALDH1A1NPSR1 | |
| SCHEMBL14159995 | 0.85 | P2RX7 (0.55) | P2RX7MDM2TGFBR1ALDH1A1MEN1 | |
| SCHEMBL14159994 | 0.85 | P2RX7 (0.55) | P2RX7MDM2TGFBR1ALDH1A1LMNA | |
| SCHEMBL14159993 | 0.85 | TGFBR1 (0.58) | P2RX7MDM2TGFBR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |