Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 15/20 | 0.61 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14160076 | 0.89 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL5188592 | 0.88 | P2RX7 (0.78) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL5188601 | 0.88 | P2RX7 (0.78) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| SCHEMBL5188598 | 0.88 | P2RX7 (0.78) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223799 | 0.87 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223802 | 0.87 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL1223804 | 0.87 | P2RX7 (0.76) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445426 | 0.82 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445424 | 0.82 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL10445425 | 0.82 | P2RX7 (0.62) | P2RX7MDM2TGFBR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |