Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 18/20 | 0.62 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390081 | 0.87 | GPR119 (0.60) | GPR119SCN9ACNR2CYP3A4CYP2C19 | |
| SCHEMBL1673837 | 0.77 | GPR119 (0.53) | GPR119SCN9ACNR2CYP3A4CYP2C19 | |
| SCHEMBL16151744 | 0.74 | GPR119 (0.53) | GPR119SCN9ACNR2CYP3A4CYP2C19 | |
| SCHEMBL1673894 | 0.74 | GPR119 (0.74) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL388948 | 0.74 | GPR119 (1.00) | GPR119 | |
| SCHEMBL386106 | 0.74 | GPR119 (0.56) | GPR119SCN9ACYP3A4CYP2C19 | |
| SCHEMBL386195 | 0.74 | GPR119 (0.74) | GPR119CYP3A4CYP2C19 | |
| SCHEMBL3424680 | 0.71 | CNR2 (0.60) | GPR119SCN9ACNR2CYP3A4CYP2C19 | |
| SCHEMBL1673891 | 0.70 | GPR119 (0.60) | GPR119SCN9ACYP3A4CYP2C19 | |
| SCHEMBL1673911 | 0.70 | GPR119 (0.60) | GPR119CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1927594-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | Arena Pharmaceuticals, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |