Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 12/20 | 0.67 |
| ▸ | RAB9A | P51151 | 11/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | MLLT1 | Q03111 | 5/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | MLLT3 | P42568 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15099490 | 0.85 | NPC1 (0.90) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL11937745 | 0.82 | TRPV1 (1.00) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL11931686 | 0.81 | NPC1 (1.00) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL18618367 | 0.79 | MLLT1 (0.95) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL14160552 | 0.79 | TP53 (0.58) | NPC1RAB9AKMT2ATP53HPGD | |
| SCHEMBL17661429 | 0.78 | NPC1 (1.00) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL16373728 | 0.78 | NPC1 (0.81) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL11931680 | 0.78 | NPC1 (1.00) | TRPV1NPC1RAB9AKMT2AS1PR1 | |
| SCHEMBL4093700 | 0.78 | ALDH1A1 (0.66) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL14160559 | 0.78 | CYP1A2 (0.67) | NPC1RAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070739-A1 | KSP ACTIVATORS | CYTOKINETICS, INC. (US) | 2008-06-12 | — | — | WO | disclosed |