Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.41 |
| ▸ | ITGAL | P20701 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DCK | P27707 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311500 | 0.77 | DCK (0.72) | DCK | |
| SCHEMBL14163253 | 0.74 | LRRK2 (0.44) | LRRK2ITGB2ICAM1ITGALKDM4E | |
| SCHEMBL14163244 | 0.74 | GRM3 (0.46) | LRRK2MAPTCHRM4 | |
| SCHEMBL14163337 | 0.72 | LRRK2 (0.42) | LRRK2KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL11981591 | 0.67 | SMO (0.46) | LRRK2ITGB2ICAM1ITGALKDM4E | |
| SCHEMBL3391134 | 0.67 | SLC18A3 (0.60) | MEN1ALDH1A1KMT2AMAPTPOLB | |
| SCHEMBL30837878 | 0.66 | LRRK2 (0.40) | LRRK2ITGB2ICAM1ITGALCYP2C19 | |
| SCHEMBL30576088 | 0.65 | CCNE2 (0.47) | ITGB2ICAM1ITGAL | |
| SCHEMBL16903676 | 0.65 | TRPA1 (0.41) | KDM4EMAPTLCAT | |
| SCHEMBL30576056 | 0.65 | F2 (0.49) | ITGB2ICAM1ITGALKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076779-A2 | 2-(PIPERIDIN-4-YL0XY)PYRIMIDIN-4-AMINE DERIVATIVES AS DEOXYCYTIDINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |