SCHEMBL14163758

SCHEMBL14163758

NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)c(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CA9 Q16790 19/20 1.00
▸ CA1 P00915 17/20 1.00
▸ CA2 P00918 17/20 1.00
▸ CA12 O43570 8/20 0.73
▸ CA14 Q9ULX7 4/20 0.73
▸ CA7 P43166 2/20 0.71
▸ USP2 O75604 1/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14163768 0.92 CA9 (0.86) CA9CA1CA2CA12CA14
SCHEMBL14163756 0.92 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163757 0.92 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163760 0.91 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163754 0.91 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163759 0.88 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163755 0.87 CA9 (0.89) CA9CA1CA2CA12CA14
SCHEMBL15828111 0.85 CA9 (0.83) CA9CA1CA2CA12CA14
SCHEMBL13070942 0.84 CA9 (1.00) CA9CA1CA2CA12CA14
SCHEMBL14163764 0.84 CA9 (0.87) CA9CA1CA2CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080138291-A1 Sulfonamide Derivatives Having Carbonic Anhydrase Inhibiting Activity and their Use as Therapeutic and Diagnostic Agents UNION LIFE SCIENCES LTD. (GB) 2008-06-12 — — US disclosed
US-20080138291-A1 Sulfonamide Derivatives Having Carbonic Anhydrase Inhibiting Activity and their Use as Therapeutic and Diagnostic Agents UNION LIFE SCIENCES LTD. (GB) 2008-06-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080138291-A1 Sulfonamide Derivatives Having Carbonic Anhydrase Inhibiting Activity and their Use as Therapeutic and Diagnostic Agents CA9, CA4, CA2 CA9 1/4885CA1 8/4885CA2 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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