SCHEMBL1417028

SCHEMBL1417028

COC(=O)c1cccc(C2OCCO2)c1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.49
NPC1 O15118 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
LOXL2 Q9Y4K0 1/20 0.46
TSHR P16473 1/20 0.46
CYP4F2 P78329 2/20 0.45
CYP4A11 Q02928 2/20 0.45
POLB P06746 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
ALDH1A1 P00352 3/20 0.43
PARP1 P09874 1/20 0.43
PPM1B O75688 1/20 0.42
KDM4E B2RXH2 1/20 0.42
KMT2A Q03164 1/20 0.42
RBP4 P02753 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27464455 0.85 TSHR (0.50) RAB9ANPC1SMN1; SMN2LOXL2TSHR
SCHEMBL4238470 0.82 MEN1 (0.48) RAB9ANPC1SMN1; SMN2ALDH1A1PARP1
SCHEMBL4246223 0.82 PARP1 (0.46) RAB9ANPC1SMN1; SMN2LMNAALDH1A1
SCHEMBL5423204 0.82 PARP1 (0.49) RAB9ANPC1GAAALDH1A1PARP1
SCHEMBL27376943 0.81 SLC2A1 (0.40) RAB9ANPC1SMN1; SMN2GAAALDH1A1
SCHEMBL27462508 0.81 PARP1 (0.40) RAB9ANPC1SMN1; SMN2POLBLMNA
SCHEMBL2282510 0.80 KMO (0.56) RAB9ASMN1; SMN2TSHRLMNAGAA
SCHEMBL2360322 0.80 NPC1 (0.71) RAB9ANPC1SMN1; SMN2LOXL2TSHR
SCHEMBL3933287 0.79 KMO (0.54) RAB9ANPC1LOXL2TSHRCYP4F2
SCHEMBL6697278 0.79 PARP1 (0.68) TSHRPOLBPARP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584263-A1 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF Chong Kun Dang Pharmaceutical Corp. (KR) 2025-07-16 EP disclosed
CN-119816495-A 1,3, 4-Oxadiazole derivative compounds as histone deacetylase 6 inhibitors and uses thereof 株式会社钟根堂 2025-04-11 CN disclosed
WO-2024054071-A1 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND USES THEREOF CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2024-03-14 WO disclosed
EP-3698805-A1 FRACTION OFZANTHOXYLUM PIPERITUM Mecox Curemed Co., Ltd. (KR) 2020-08-26 EP disclosed
CN-111574529-A Muscarinic receptor M3 antagonists and β 2-adrenergic receptor agonist bridged ring derivatives 四川海思科制药有限公司 2020-08-25 CN disclosed
WO-2019078386-A1 FRACTION OF ZANTHOXYLUM PIPERITUM LEAF EXTRACT, EFFECTIVE FOR PAIN RELIEF 메콕스큐어메드 주식회사 2019-04-25 WO disclosed
EP-3345904-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY Chiesi Farmaceutici S.p.a. (IT) 2018-07-11 EP disclosed
EP-3345904-A1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY Chiesi Farmaceutici S.p.a. (IT) 2018-07-11 EP disclosed
EP-2928889-B1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARM SPA (IT) 2018-03-21 EP disclosed
EP-2928889-B1 COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY CHIESI FARM SPA (IT) 2018-03-21 EP disclosed
EP-0469833-B1 N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them LILLY CO ELI (GB) 1999-09-08 EP disclosed
CN-1040108-C Pharmaceutical compounds LILLY INDUSTRIES LTD (GB) 1998-10-07 CN disclosed
EP-0399818-B1 Diarylstyrylquinoline diacids MERCK FROSST CANADA INC (CA) 1995-08-16 EP disclosed
US-5281593-A Pharmaceuticals LILLY INDUSTRIES LIMITED (GB) 1994-01-25 US disclosed
US-5204358-A Antiallergens; antiinflammatory agents; treatment of asthma, rhinitis, bronchitis and skin diseases MERCK FROSST CANADA, INC. (CA) 1993-04-20 US disclosed
CN-1061413-A Medicinal compound LILLY INDUSTRIES LTD (GB) 1992-05-27 CN disclosed
US-5104882-A Leukotriene antagonists MERCK FROSST CANADA, INC. (CA) 1992-04-14 US disclosed
EP-0469833-A1 N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them LILLY INDUSTRIES LIMITED (GB) 1992-02-05 EP disclosed
EP-0399818-A1 Diarylstyrylquinoline diacids MERCK FROSST CANADA INC. (CA) 1990-11-28 EP disclosed
EP-0318093-A2 Diarylquinoline diacids and their use as medicaments MERCK FROSST CANADA INC. (CA) 1989-05-31 EP disclosed